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Cannabinoids for Liver Cancer - Do CBD, CBG & THC help?

Cannabinoids are a group of chemical compounds found in the cannabis plant (Cannabis sativa). They interact with specific receptors in the human body's endocannabinoid system (ECS), which is involved in virtually every physiological process.

CBG, CBD, and THC are three well-known cannabinoids:

Cannabigerol (CBG): CBG is often referred to as the "mother cannabinoid" because it is a precursor to every other cannabinoid. It is usually present in low concentrations in most cannabis strains. CBG is non-intoxicating and has shown potential therapeutic properties, including anti-inflammatory, analgesic (pain-relieving), and neuroprotective effects. It is also being studied for its potential to treat conditions like glaucoma, inflammatory bowel disease, and certain cancers.

Cannabidiol (CBD): CBD has gained significant attention due to its potential therapeutic benefits and recent change in legal status. Unlike THC, CBD is non-impairing, meaning it does not produce a "high." It has shown promise in relieving pain, reducing anxiety and depression, alleviating symptoms of epilepsy, and possessing anti-inflammatory properties. Like CBG, CBD is available in various forms, including oils, capsules, topicals, and edibles and can be legally obtained in most states.

Tetrahydrocannabinol (THC): THC is the primary psychoactive compound in cannabis responsible for the "high" or euphoric effects. It binds to cannabinoid receptors in the brain and central nervous system. Apart from its recreational use, THC also has potential therapeutic applications, including pain relief, nausea and vomiting reduction, and appetite stimulation. However, THC can have side effects such as anxiety, impaired memory, and coordination, and it may not be suitable for everyone. THC is legally available in various forms and concentrations for Adult-Use or Medicinally. Cannabis may remain illegal federally, but in most states, it’s accessible for medical or adult personal use.

Per CNN:

On May 30, Minnesota became the 23rd state to legalize recreational marijuana.
In 38 states and Washington, D.C., voters or legislators have approved comprehensive medical programs. In late March, Kentucky Governor Andy Beshear signed a law legalizing medical use in his state, but it won’t go into effect until 2025.
Twenty-three states and Washington D.C., have passed legal adult recreational use policies . Maryland will enact its legal adult use policy in July, and Minnesota’s law will go into effect in August.

CBD, CBG, and THC are promising forms of treatment for liver cancer. Over the last few years, several studies have found that these natural compounds may be effective in helping to drastically reduce inflammation, ease side effects from standard of care treatments, and even inhibit cancer cell growth. Here are just a few ways that CBD, CBG, and THC can help treat liver cancer:

  1. Anti-Nausea Benefits: THC is known for its anti-nausea benefits, which can help ease some of the painful symptoms of chemotherapy. CBD and CBG, which are non-psychoactive, have also been found to reduce nausea and even anxiety associated with cancer treatments.

  2. Pain Management: Studies have shown that CBD, CBG, and medical cannabis can provide patients with relief from pain associated with cancer treatments, including surgery. When taken before and after procedures, these compounds can help to reduce swelling, as well as improve sleep quality.

  3. Regulation of Appetite: THC and CBD have also been found to be helpful in regulating appetite. Adding cannabinoids to a patient’s treatment plan can help to increase appetite and improve nutrient absorption.

  4. Preventing Tumor Growth: Researchers are now beginning to understand how CBD, CBG, and medical cannabis fight cancer on a cellular level. Studies have found that they can be a powerful weapon in stopping tumor growth and the spread of cancer cells.

These natural compounds are proving to be a powerful and safe way to treat liver cancer, and it’s exciting to see the progress being made in using CBD, CBG, and THC to treat this disease. If you or someone you know has liver cancer, be sure to talk to a knowledgeable cannabis healthcare provider or coach about the potential benefits of these natural compounds.

Studies have found that cannabidiol (CBD) and cannabigerol (CBG), can help cause cell death and slow the growth of three different types of cells from liver cancer. Lab tests suggest that these substances may work as treatments for this type of cancer. THC (tetrahydrocannabinol) was also shown to help slow the growth of cells from liver cancer.

Check out a few studies we found interesting:

Type of Study: Laboratory Study

Study Result: Positive

Cannabinoids Studied: Cannabidiol (CBD), Cannabigerol (CBG)

Phytocannabinoid Source: Unspecified

Form of Administration: In vitro

Study Location(s): United States

Year of Pub: 2022

Key Findings: This in vitro study of 3 different cholangiocarcinoma cell lines found that both cannabidiol (CBD) and cannabigerol (CBG) were effective in causing cell death and reducing cellular proliferation. This work could lead to therapeutic uses of CBD and CBG in cancer treatments for cholangiocarcinoma.

Type of Study: Animal Study

Study Result: Positive

Cannabinoids Studied: Cannabidiol (CBD)

Phytocannabinoid Source: Unspecified

Chemotype: Chemotype III

Study Location(s): China

Year of Pub: 2021

Key Findings: Resulting data shown that CBD was able to effectively suppresses hepatocellular carcinoma (HCC) cell growth in vivo and in vitro. Furthermore, CBD was able to induces pyroptosis (a highly inflammatory form of programmed cell death) in HCC Cells.

Type of Study: Laboratory Study

Study Result: Positive

Cannabinoids Studied: Tetrahydrocannabinol (THC), JWH-x Synthetic Cannabinoids

Phytocannabinoid Source: Not Applicable

Chemotype: Chemotype I

Form of Administration: In vitro

Receptors Studied: CB2

Study Location(s): Spain

Year of Pub: 2011

Key Findings: Results show that Δ(9)-tetrahydrocannabinol (Δ(9)-THC, the main active component of Cannabis sativa) and JWH-015 (a cannabinoid receptor 2 (CB(2)) cannabinoid receptor-selective agonist) reduced the viability of the human HCC cell lines HepG2 (human hepatocellular liver carcinoma cell line) and HuH-7 (hepatocellular carcinoma cells), an effect that relied on the stimulation of CB(2) receptor. Results also show that Δ(9)-THC- and JWH-015-induced autophagy relies on tribbles homolog 3 (TRB3) upregulation, and subsequent inhibition of the serine-threonine kinase Akt/mammalian target of rapamycin C1 axis and adenosine monophosphate-activated kinase (AMPK) stimulation.

Type of Study: Laboratory Study

Study Result: Positive

Cannabinoids Studied: Tetrahydrocannabinol (THC)

Phytocannabinoid Source: Unspecified

Chemotype: Chemotype I

Study Location(s): Thailand

Year of Pub: 2010

Key Findings: THC showed retardation of cholangiocarcinoma cells, growth, and metastasis.

Overall, while there is preliminary evidence suggesting that CBG, CBD, and THC may have anti-cancer properties and could potentially be beneficial in liver cancer treatment, further research is needed.

If you’re new to cannabis medicine it’s wise to work with a knowledgeable coach or healthcare practitioner. You can find a doctor at the Society of Cannabis Clinicians website using their Practitioner Finder Tool and of course, you can always find a time that works for you at - we always love to share about how beneficial this natural, healing herb can be with education.

Whether or not you live in a legal cannabis state, you can get premium CBD, CBG and other legal "hemp" based cannabinoids delivered anywhere in the US directly from one of our recommended affiliate brands including Lazarus Naturals, Myriam's Hemp or HEALER. #CBD #CBG #healing #cancer #apoptosis #painrelief #anxietyrelief #sleep

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