Cannabis-based therapeutics have been used historically as an analgesic for various types of pains including chronic, central, peripheral, nociceptive, inflammatory, pathological as well as mental and emotional types.
Mounting evidence is beginning to explain the underlying mechanisms of how modulating components of the endocannabinoid system activates a number of mechanisms involved in realizing effective pain relief.
More than a dozen published papers including 4 clinical trials have directly examined the impact of cannabinoids on cancer-induced pain. All clinical trials conducted on humans suggest a positive therapeutic potential in alleviating cancer pain.
All three cannabis chemotypes (type I=high THC, type II=1:1 balanced CBD & THC, type III=high CBD) may produce analgesic effects in this patient population albeit by different mechanisms thus offering patients a choice about what kind of cannabis experience they wish to have. For instance, those wishing to avoid changes in cognition may wish to utilize a chemotype III (high CBD).
Rylie Maedler has been using cannabis oil since 2013, when she was 7 years old, to fight the cancer that was eating the bones of her face causing tremendous pain. She’s in remission, NED for many years and inspiring people across the world. https://youtu.be/xvOEzUvjP94 Rylie still uses medical cannabis every day to stay healthy.
The Efficacy of Medical Marijuana in the Treatment of Cancer-Related Pain Key Findings: The authors concluded that the use of medical cannabis improved oncology patients' ESAS scores despite opioid dose reductions and ought be considered a viable adjuvant therapy for palliative management. https://pubmed.ncbi.nlm.nih.gov/32101075/ Reducing opioids is a real blessing for many people.
Cannabis, Cannabinoids and Cannabis-Based Medicines in Cancer Care Key Findings: Cannabis or cannabinoid-based therapeutics may be useful in managing symptoms related to cancer or its treatment. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882944/
The effects of cannabis, cannabinoids, and their administration routes on pain control efficacy and safety: A systematic review and network meta-analysis Key Findings: Evidence reveals that various forms and combination of THC and CBD may have have efficacy in the treatment of different types of pain: THC/CBD and THC via oromucosal route may reduce cancer-induced pain (as well as neuropathic pain); THC via oral route may also reduce cancer-induced pain; standardized dried cannabis (with THC; SCT) via inhalation route may show efficacy for neuropathic pain, and standardized cannabis extract (with THC; SCET) via oral route for nociceptive pain. https://www.japha.org/article/S1544-3191(19)30353-X/fulltext